Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer
Overview
RATIONALE: Learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments. PURPOSE: This clinical trial is looking at the neurological effects of chemotherapy and radiation therapy in patients with colon cancer.
Full Title of Study: “Neurological Effects of Chemotherapy and Radiation Treatment: Colon Cancer”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: August 2006
Detailed Description
OBJECTIVES: Primary – Identify the nature and long-term ramifications of CNS injury as a result of cancer treatment in patients with colon cancer. Secondary – Analyze differences in cognitive measures and MRI data in these patients. – Correlate MRI measures with cognitive performance in these patients. OUTLINE: Patients undergo cognitive performance assessment and MRI. PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.
Interventions
- Procedure: cognitive assessment
- Procedure: magnetic resonance imaging
- Procedure: management of therapy complications
Clinical Trial Outcome Measures
Primary Measures
- Nature and long-term ramifications of CNS injury as a result of cancer treatment
Secondary Measures
- Differences in cognitive measures and MRI data
- Relationship between MRI measures and cognitive performance
Participating in This Clinical Trial
DISEASE CHARACTERISTICS:
- Diagnosis of colon cancer – Received chemotherapy and radiotherapy for colon cancer PATIENT CHARACTERISTICS: – Not specified PRIOR CONCURRENT THERAPY: – See Disease Characteristics
Gender Eligibility: All
Minimum Age: N/A
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- University of Arizona
- Collaborator
- National Cancer Institute (NCI)
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Sheryl Reminger, MD, Study Chair, University of Arizona
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