Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer

Overview

RATIONALE: Learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments. PURPOSE: This clinical trial is looking at the neurological effects of chemotherapy and radiation therapy in patients with colon cancer.

Full Title of Study: “Neurological Effects of Chemotherapy and Radiation Treatment: Colon Cancer”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: August 2006

Detailed Description

OBJECTIVES: Primary – Identify the nature and long-term ramifications of CNS injury as a result of cancer treatment in patients with colon cancer. Secondary – Analyze differences in cognitive measures and MRI data in these patients. – Correlate MRI measures with cognitive performance in these patients. OUTLINE: Patients undergo cognitive performance assessment and MRI. PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.

Interventions

  • Procedure: cognitive assessment
  • Procedure: magnetic resonance imaging
  • Procedure: management of therapy complications

Clinical Trial Outcome Measures

Primary Measures

  • Nature and long-term ramifications of CNS injury as a result of cancer treatment

Secondary Measures

  • Differences in cognitive measures and MRI data
  • Relationship between MRI measures and cognitive performance

Participating in This Clinical Trial

DISEASE CHARACTERISTICS:

  • Diagnosis of colon cancer – Received chemotherapy and radiotherapy for colon cancer PATIENT CHARACTERISTICS: – Not specified PRIOR CONCURRENT THERAPY: – See Disease Characteristics

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Arizona
  • Collaborator
    • National Cancer Institute (NCI)
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Sheryl Reminger, MD, Study Chair, University of Arizona

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