Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids

Overview

We assume that the combination of systemic steroids and inhaled steroid in the first hour of treatment in the ER will decrease the admission rate and improve faster the pulmonary function. 120 patients refferd to the ER due to asthma attack aged 18-60 with PFR < 60% 0o predicted will participate in the study after giving informed consent. The usual treatment in the ER is inhalation of Beta 2 short acting and I.V solumedrol 120 mg . The study group will recieve in addition 3 inhalation of Budesonide 1000 microgram each during the first hour. The controlled group will recieve Nacl 0.9% PFR will be followed 0 30 60 120 min.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)

Detailed Description

Primary end points- PFT improvment and admission rate.

Interventions

  • Drug: inhalation of corticosteroids

Clinical Trial Outcome Measures

Primary Measures

  • PFT improvment
  • Admission rate

Participating in This Clinical Trial

Inclusion Criteria

  • Asthmatic patients aged 18-60 with PFR < 60% of predicted Exclusion Criteria:

  • Patients with other chronic diseases – cardiac renal hepatic etc will be excluded

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Soroka University Medical Center
  • Overall Official(s)
    • Dov Heimer, M.D, Principal Investigator, BGU Soroka medical center
  • Overall Contact(s)
    • Dov Heimer M.D. Heimer, AS. Proffessor, 972 8 6400807, heimerd@clalit.org.il

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