Polymorphisms in Inflammatory Cytokines Genes in Subjects With Obstructive Sleep Apnea


Obstructive sleep apnea is a common sleep disorder. It is known to be related with increased body mass, abdominal obesity, insulin resistance and hypertension. It is currently believed to be a feature of the metabolic syndrome. Other features of the metabolic syndrome-such as insulin resistace were found related to inflammation and inflammatory cytokines. Several polymorphisms in the genes that encode interleukin 6,inteleukin 10 and TNF-alpha have significant influence on the amounts of cytokine production. we thus hypothesize that polymorphisms related to increased pruduction are more common in subjects with OSA than in matched controls

Full Title of Study: “A Cross Sectional Study of Patients With Obstructive Sleep Apnea for Polymorphisms in Genes of Inflammatory Cytokines.”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Other

Detailed Description

Patients attending a sleep apnea clinic for evluation will be recruited. Patients found positive for OSA will be compared to the patients with a negative study for OSA for the prevalence of polymorphisms in genes of inflammatory cytokines and cytokine levels

Participating in This Clinical Trial

Inclusion Criteria

  • Patients attending the sleep apnea clinic for evaluation Exclusion Criteria:

  • patients known to have inflammatory conditions

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 75 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Shaare Zedek Medical Center
  • Overall Official(s)
    • mates mates, MD, Study Director, Ben-Gurion University of the Negev
  • Overall Contact(s)
    • michal mates, MD, 02-6555111, rheum@szmc.org.il

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