Helium-Hyperoxia and 6MWT Distance in COPD

Overview

We assessed the effect of altering inspired gas on the 6MWT distance in COPD. We hypothesized that HeO2 would improve walking distance and reduce shortness of breath compared to both RA and O2, and potentially improve quality of life for COPD patients.

Full Title of Study: “The Effects of Helium-Hyperoxia on 6-Minute Walking Distance in Chronic Obstructive Pulmonary Disease – A Randomized, Controlled Trial”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Treatment
    • Masking: Single

Detailed Description

We hypothesized that inspiring helium-hyperoxia (HeO2) would significantly improve 6-minute walking test (6MWT) distance in Chronic Obstructive Pulmonary Disease (COPD) subjects. This was a blinded, randomized crossover study. At Visit 1 we assessed pulmonary function, exercise capacity and 6MWT distance. Visits 2 and 3 consisted of four 6MWT with different inspired gases: room air by mask (RA), 100% O2 by mask (Mask O2), 100% O2 by nasal prongs (Nasal O2), and 70% He/30% O2 by mask (HeO2). Walking distance, shortness of breath, leg fatigue, O2 saturation and heart rate (HR) were assessed

Interventions

  • Drug: Oxygen
  • Drug: Helium

Clinical Trial Outcome Measures

Primary Measures

  • 6 minute walking distance

Secondary Measures

  • shortness of breath
  • leg fatigue
  • arterial oxygen saturation

Participating in This Clinical Trial

Inclusion Criteria

  • Exertional dyspnea – Activity limitation – COPD Exclusion Criteria:

  • Recent exacerbation (< 4 wks) – Supplemental O2 – Significant cardiovascular/musculoskeletal abnormalities

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Saskatchewan
  • Collaborator
    • Nova Scotia Health Authority
  • Overall Official(s)
    • Darcy D Marciniuk, MD, FRCP(C), Principal Investigator, University of Saskatchewan

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