Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock

Overview

Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers. The investigators hypothesize, therefore, that there is a significant difference in the concentrations of inflammatory and infectious markers in the rectal mucosa between patients with septic shock and healthy controls.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective

Interventions

  • Procedure: Rectal biopsy
    • Rectal biopsy.
  • Procedure: Measurement of inflammatory markers in the rectal mucosa
    • IL-6, TNF-alfa.
  • Procedure: Measurement of rectal lactic acid
    • Equilibrium dialysis.

Participating in This Clinical Trial

Inclusion Criteria

  • Septic shock Exclusion Criteria:

  • Age < 18 years – No next of kin – Pathology of the descending or sigmoid colon or rectum – Pregnancy – 1st degree relatives with inflammatory bowel disease – Severe coagulopathy

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Herlev Hospital
  • Provider of Information About this Clinical Study
    • Michael Ibsen, Rigshospitalet
  • Overall Official(s)
    • Michael Ibsen, MD, Principal Investigator, Dept. of Intensive Care 4131, Rigshospitalet, Copenhagen, Denmark
  • Overall Contact(s)
    • Michael Ibsen, MD, + 45 45 35 94 18, micibs@dadlnet.dk

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