The Use of Nasal Phenylephrine in Infants With Bronchiolitis

Overview

Drops of either saline or phenylephrine are placed in the nose of infants less than 12 months of age to determine if it helps them to breathe easier.

Full Title of Study: “A Randomized, Double-Blinded Placebo Control Trial of Nasal Phenylephrine in Infants With Bronchiolitis”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: Double
  • Study Primary Completion Date: June 2005

Interventions

  • Drug: Phenylephrine

Clinical Trial Outcome Measures

Primary Measures

  • Respiratory Distress Assessment Index at 5 minutes, 60 minutes, and 180 minutes.

Secondary Measures

  • Respiratory rate, oxygen saturation and use of supplemental oxygen at 5, 60, and 180 minutes.

Participating in This Clinical Trial

Inclusion Criteria

  • Age 4 weeks to 12 months; admitting diagnosis of bronchiolitis; admitted to hospital's bronchiolitis pathway, admitted during weekdays, need for nasal suctioning. Exclusion Criteria:

  • Congenital heart disease, history of hypertension, previous wheezing, prior use of inhaled corticosteroids, gestational age at birth of <34 weeks.

Gender Eligibility: All

Minimum Age: 4 Weeks

Maximum Age: 12 Months

Investigator Details

  • Lead Sponsor
    • Akron Children’s Hospital
  • Provider of Information About this Clinical Study
    • Nathan Kraynack, M.D., Akron Children’s Hospital
  • Overall Official(s)
    • Rachel Konda-Sundheim, MD, MD, Principal Investigator, Children’s Hospital Medical Center of Akron

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