Use of Erythromycin in Mustard-Induced Bronchiolitis

Overview

We looked for the effectiveness of low-dose long-term prescription of erythromycin in mustard-induced bronchiolitis obliterans

Full Title of Study: “Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: Double

Interventions

  • Drug: Erythromycin

Participating in This Clinical Trial

Inclusion Criteria

  • Documented chemical exposure
  • Clinical, spirometric and radiological findings were compatible with BO on High Resolution Computed Tomography (HRCT)
  • Non-responsiveness to high dose bronchodilator therapy

Exclusion Criteria

  • Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an infection that necessitated the use of an antibiotic
  • History of cigarette smoking and occupational exposure to toxic agents of hypersensitivity to macrolides
  • History of treatment with a systemic antibiotic within 7 days before the start of the study
  • Any investigational medicine within 4 weeks of the study
  • History of antibiotic injection within 6 weeks before the study
  • Concomitant Theophylline or Carbamazepine, unless their serum concentrations were regularly monitored
  • Patients who were in the exacerbation phase of their respiratory complications
  • Need to use medications interact with macrolides such as Digoxin, Theophylline and Carbamazepine
  • Systemic antibiotics
  • Systemic Corticosteroids
  • Admission to the hospital
  • Abnormal kidney or liver function

Gender Eligibility: Male

Minimum Age: N/A

Maximum Age: N/A

Investigator Details

  • Lead Sponsor
    • Baqiyatallah Medical Sciences University
  • Overall Official(s)
    • Mostafa Ghanei, Professor, Study Director, Research Center of Chemical Injuries, Baqyatallah Medical Sciences University, Tehran, Iran

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