BNP Guided Care in Addition to Multidisciplinary Care

Overview

HF is associated with repeated hospitalisations and poor prognosis.The aim of this study is to investigate whether BNP-guided care (BGC) in addition to multidisciplinary management(MM) improves outcome compared to HNC alone or usual care (UC) for decompensated HF patients after discharge. Patients hospitalised with cardiac decompensation in 9 Viennese hospitals are randomised to BGC, MM alone, or UC. MM includes 2 consultations of a heart failure (HF) specialist 10 days and 2 months after discharge for recommending medical optimisation and care by a specialised HF nurse including 4 home visits and telephone contact. In addition, BGC includes intensified increase of medical treatment during repeated follow-up visits in a HF clinic in patients with an Nt-BNP level above 2200pg/ml at discharge.

Full Title of Study: “NT-BNP Guided Care in Addition to Multidisciplinary Care in Patients With Chronic Heart Failure A Three-Arm, Prospective, Randomised Study”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Masking: None (Open Label)

Interventions

  • Procedure: BNP-guided care in addition to multidisciplinary management

Clinical Trial Outcome Measures

Primary Measures

  • Heart failure rehospitalisation rate;
  • combined endpoint death or heart failure rehospitalisation;

Participating in This Clinical Trial

Inclusion Criteria

1. Clinical signs and symptoms of cardiac decompensation during the present hospitalisation 2. NYHA class III or IV at time of admission 3. Cardiothoracic ratio > 0.5, and/or left ventricular ejection fraction <40% documented by echocardiography Exclusion Criteria:

-

Gender Eligibility: All

Minimum Age: 19 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Medical University of Vienna
  • Overall Official(s)
    • Richard Pacher, MD, Principal Investigator, Medical University of Vienna

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