Daptomycin or Vancomycin in Treating Bacteria in the Blood in Patients With Neutropenia Caused By Chemotherapy

Overview

RATIONALE: Antibiotics, such as daptomycin and vancomycin, may be effective in treating bacteria in the blood. It is not yet known whether daptomycin is more effective than vancomycin in treating bacteria in the blood in patients with neutropenia caused by chemotherapy. PURPOSE: This randomized clinical trial is studying daptomycin to see how well it works compared with vancomycin in treating bacteria in the blood in patients with neutropenia caused by chemotherapy.

Full Title of Study: “An Open-Label, Pilot Study of Daptomycin vs. Vancomycin for Treatment of Gram-Positive Bacteremia in Neutropenic Cancer Patients”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Supportive Care
    • Masking: None (Open Label)
  • Study Primary Completion Date: March 2006

Detailed Description

OBJECTIVES: Primary – Compare the safety of daptomycin vs vancomycin in cancer patients with chemotherapy-induced neutropenia and gram-positive bacteremia. – Compare the efficacy of these drugs, in terms of fever resolution, bacteremia resolution, inflammation indicators reduction, implanted catheter salvage, and reduced need for antifungal therapy, in these patients. OUTLINE: This is an open-label, randomized, pilot study. Patients are randomized to 1 of 2 treatment arms. – Arm I: Patients receive daptomycin IV over 30 minutes once daily. – Arm II: Patients receive vancomycin IV over 60 minutes twice daily. Treatment in both arms continues for approximately 7-14 days or until microbiologic failure, unsatisfactory clinical (symptomatic) response, or fever and neutropenia is resolved (absolute neutrophil count ≥ 1,000/mm^3 on ≥ 2 consecutive days). Patients may be removed from the study if the isolate is found to be sensitive to the original antibiotics or resistant to either of the study drugs. After completion of study therapy, patients are followed at 6 and 12 weeks. PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

Interventions

  • Drug: daptomycin
  • Drug: vancomycin

Arms, Groups and Cohorts

  • Active Comparator: vancomycin
  • Experimental: daptomycin

Clinical Trial Outcome Measures

Primary Measures

  • determine the efficacy of daptomycin to treat gram positive infections
    • Time Frame: day 7
  • determine the safety of daptomycin in neutropenic patients
    • Time Frame: day 7

Participating in This Clinical Trial

DISEASE CHARACTERISTICS:

  • Diagnosis of a malignancy – Chemotherapy-induced neutropenia (absolute neutrophil count < 500/mm^3) – Two or more blood cultures positive for gram-positive cocci – At least 0.2 colony-forming units/mL on lysis-centrifugation culture – Currently receiving broad-spectrum antimicrobial therapy appropriate for febrile neutropenia – No meningitis, endocarditis, osteomyelitis, or pneumonia (by clinical or radiologic criteria) PATIENT CHARACTERISTICS: – Life expectancy ≥ 7 days – No allergy or intolerance to vancomycin or daptomycin – Creatinine clearance ≥ 30 mL/min – Not pregnant or nursing – Negative pregnancy test – Fertile patients must use effective contraception during and for at least 30 days after completion of study treatment – No underlying myopathy or neurologic disease (e.g., Guillan-Barre or multiple sclerosis) PRIOR CONCURRENT THERAPY: – See Disease Characteristics – No concurrent HMG CoA reductase inhibitors (statins) – No concurrent gemfibrozil or clofibrate

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: 120 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Wake Forest University Health Sciences
  • Collaborator
    • National Cancer Institute (NCI)
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Kevin High, MD, Study Chair, Wake Forest University Health Sciences

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.