Urinary Aquaporin 2 Excretion After Methylprednisolone in Fasting Healthy Humans

Overview

We wanted to test the hypotheses that methylprednisolone up regulates u-AQP-2 in fasting healthy humans

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Masking: Single
  • Study Primary Completion Date: February 2007

Interventions

  • Drug: Methylprednisolone

Clinical Trial Outcome Measures

Primary Measures

  • u-AQP-2
  • FeNa+

Participating in This Clinical Trial

Inclusion Criteria

  • (1) Genders; both mal and female – (2) Age; 18- 65 years old – (3) BMI; below 30 – (4) Females had to bee in oral contraceptive treatment Exclusion Criteria:

  • (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs – (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose) – (3) Albuminuria or glucosuria – (4) Cancer – (5) Arterial hypertension – (6) Alcohol abuse – (7) Use of tobacco – (8) Medical treatment, except oral contraceptives – (9) Pregnancy or breast feeding – (10) Medicine abuse – (11) Donation of blood less than 1 month before the study.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Regional Hospital Holstebro
  • Overall Official(s)
    • Erling B Pedersen, Professor, Study Chair, Holstebro Hospital, 7500 Holstebro, Denmark
    • Thomas G Knudsen, MD, Principal Investigator, Holstebro Sygehus

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