This research will investigate the effect of garlic oil extract when added to daily diet on inflammatory mediators and blood clotting activation.
Full Title of Study: “Effect of Garlic Oil Macerate on Inflammatory Mediators in Healthy Normal Weight and Obese Subjects.”
- Study Type: Interventional
- Study Design
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: None (Open Label)
To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.
- Drug: Garlic Oil Macerate
Clinical Trial Outcome Measures
- 1. To examine the pharmacokinetics of the garlic oil macerate.
- 2. To examine the effect of garlic oil macerate on inflammatory mechanisms at the cellular and molecular level.
Participating in This Clinical Trial
- 18 years of age and older – Normal subjects with BMI <25, obese subjects with BMI >30 – Subjects who have consented to adhere to the diet, regular weekly visits, and blood draws. Exclusion Criteria:
- Subjects on any antioxidant medication. – Patient on non-steroidal anti-inflammatory drug. – On any agent with antioxidant properties. – History of drug or alcohol abuse. – Any life threatening disease. – On any agent with significant antioxidant properties. – Taking garlic extracts in the diet regularly.
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
- Lead Sponsor
- Albany Medical College
- Overall Official(s)
- Howard S Smith, MD, Principal Investigator, Albany Medical College
- Shaker A Mousa, PhD, Principal Investigator, Albany College of Pharmacy
- Ahmad Aljada, PhD, Principal Investigator, Albany College of Pharmacy
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