Quantifying Nitrous Oxide Effect on Depth of Anaesthesia Using Theoretically Based Time Series Modelling

Overview

Our hypothesis is that a new method of depth of anaesthesia monitoring, using theoretically based time series modelling will result in improved ability to determine nitrous oxide anaesthetic effect

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Diagnostic
    • Masking: Single (Participant)
  • Study Primary Completion Date: August 2005

Detailed Description

We randomised patients to 0% 33% or 66% nitrous oxide during sevoflurane induction and measured anesthetic endpoints.

Interventions

  • Drug: Nitrous oxide
    • nitrous oxide by inhalation during induction

Arms, Groups and Cohorts

  • Placebo Comparator: 1
    • 0% nitrous oxide
  • Active Comparator: 2
    • 33% nitrous oxide
  • Active Comparator: 3
    • 66% nitrous oxide

Clinical Trial Outcome Measures

Primary Measures

  • EEG index value during three concentrations of nitrous oxide
    • Time Frame: During induction of anaesthesia

Participating in This Clinical Trial

Inclusion Criteria

  • Aged 18 years or older – Presenting for surgery under general anaesthesia Exclusion Criteria:

  • Poor English language comprehension – Risk of reflux – Epilepsy or other EEG abnormality

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Melbourne Health
  • Collaborator
    • Australian and New Zealand College of Anaesthetists
  • Provider of Information About this Clinical Study
    • David Breeze, Cortical Dynamics
  • Overall Official(s)
    • Kate Leslie, MD, Principal Investigator, Melbourne Health

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