Quantifying Nitrous Oxide Effect on Depth of Anaesthesia Using Theoretically Based Time Series Modelling
Overview
Our hypothesis is that a new method of depth of anaesthesia monitoring, using theoretically based time series modelling will result in improved ability to determine nitrous oxide anaesthetic effect
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Diagnostic
- Masking: Single (Participant)
- Study Primary Completion Date: August 2005
Detailed Description
We randomised patients to 0% 33% or 66% nitrous oxide during sevoflurane induction and measured anesthetic endpoints.
Interventions
- Drug: Nitrous oxide
- nitrous oxide by inhalation during induction
Arms, Groups and Cohorts
- Placebo Comparator: 1
- 0% nitrous oxide
- Active Comparator: 2
- 33% nitrous oxide
- Active Comparator: 3
- 66% nitrous oxide
Clinical Trial Outcome Measures
Primary Measures
- EEG index value during three concentrations of nitrous oxide
- Time Frame: During induction of anaesthesia
Participating in This Clinical Trial
Inclusion Criteria
- Aged 18 years or older – Presenting for surgery under general anaesthesia Exclusion Criteria:
- Poor English language comprehension – Risk of reflux – Epilepsy or other EEG abnormality
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Melbourne Health
- Collaborator
- Australian and New Zealand College of Anaesthetists
- Provider of Information About this Clinical Study
- David Breeze, Cortical Dynamics
- Overall Official(s)
- Kate Leslie, MD, Principal Investigator, Melbourne Health
Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.