Randomized Controlled Trial of Doxycycline to Prevent Acquisition of Mycoplasma Pneumoniae in an Outbreak Setting

Overview

This study was designed to determine whether taking daily doxycycline during an outbreak of Mycoplasma pneumoniae could prevent a person from getting infected and interrupt ongoing disease transmission during an outbreak. Doxycycline is a treatment for Mycoplasma pneumoniae, but it is not certain that the drug could prevent disease if used prophylactically.

Full Title of Study: “A Double-Blind, Randomized Placebo-Controlled Trial of Doxycycline for Chemoprophylaxis in the Setting of an Outbreak of Mycoplasma Pneumoniae”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Masking: Double

Interventions

  • Drug: Doxycycline treatment

Participating in This Clinical Trial

Inclusion Criteria

  • Working at hospital facility where outbreak of Mycoplasma pneumoniae occured Exclusion Criteria:

  • Pregnant, on antiseizure medications, allergic to macrolide antibiotics

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Centers for Disease Control and Prevention
  • Overall Official(s)
    • Julia A Schillinger, MD, Principal Investigator, Centers for Disease Control and Prevention

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