The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids


The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association. The investigators hypothesize that in patients with obesity and the metabolic syndrome, an increased intracellular concentration of long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and sympathetic activation. The investigators aimed to assess this effect of free fatty acids on the adenosine system in healthy volunteers.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Educational/Counseling/Training
    • Masking: Single


  • Drug: Intravenous infusion of Intralipid/heparin
  • Drug: Intravenous infusion of Glycerol/heparin

Clinical Trial Outcome Measures

Primary Measures

  • Forearm blood flow
  • Vasoactive effect of caffeine
  • Sympathetic activity (noradrenaline spillover, spectral analysis)

Participating in This Clinical Trial

Inclusion Criteria

  • Healthy volunteers Exclusion Criteria:

  • Pregnancy – Asthma – Use of medication – Cardiovascular/pulmonary disease and diabetes

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Radboud University Medical Center
  • Collaborator
    • ZonMw: The Netherlands Organisation for Health Research and Development
  • Overall Official(s)
    • Paul Smits, MD, PhD, Principal Investigator, Radboud University Medical Center


Bakker SJ, Gans RO, ter Maaten JC, Teerlink T, Westerhoff HV, Heine RJ. The potential role of adenosine in the pathophysiology of the insulin resistance syndrome. Atherosclerosis. 2001 Apr;155(2):283-90.

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