The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association. The investigators hypothesize that in patients with obesity and the metabolic syndrome, an increased intracellular concentration of long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and sympathetic activation.
The investigators aimed to assess this effect of free fatty acids on the adenosine system in healthy volunteers.
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Educational/Counseling/Training
- Masking: Single
- Drug: Intravenous infusion of Intralipid/heparin
- Drug: Intravenous infusion of Glycerol/heparin
Clinical Trial Outcome Measures
- Forearm blood flow
- Vasoactive effect of caffeine
- Sympathetic activity (noradrenaline spillover, spectral analysis)
Participating in This Clinical Trial
- Healthy volunteers
- Use of medication
- Cardiovascular/pulmonary disease and diabetes
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 40 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
- Lead Sponsor
- Radboud University
- ZonMw: The Netherlands Organisation for Health Research and Development
- Overall Official(s)
- Paul Smits, MD, PhD, Principal Investigator, Radboud University
Bakker SJ, Gans RO, ter Maaten JC, Teerlink T, Westerhoff HV, Heine RJ. The potential role of adenosine in the pathophysiology of the insulin resistance syndrome. Atherosclerosis. 2001 Apr;155(2):283-90.
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