Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study

Overview

In this study, changes in electroencephalogram (EEG) and the hemodynamic state during ventricular fibrillation or induced ventricular tachycardia are investigated.

Full Title of Study: “Change of EEG Activity and Cerebral Circulation During Induced Ventricular Fibrillation and Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in EP Study”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)

Detailed Description

Patients with a high risk of malignant tachyarrhythmia are routinely investigated by programmed electrophysiological study (EPS). To investigate the hemodynamic effects of ventricular arrhythmia to cerebral circulation an EEG and transcranial ultrasound are conducted simultaneously during the EPS. Before and after the EPS a neuropsychological test and an investigation of a specific blood sample (Neuron Specific Enolase, NSE) is done.

Interventions

  • Device: EEG

Participating in This Clinical Trial

Inclusion Criteria

  • Age > 18 years – Positive agreement – EPS for primary and secondary prophylaxis of a malignant ventricular tachyarrhythmia: – primary prophylaxis: Brugada syndrome, long QT syndrome, cardiomyopathy, short QT syndrome – secondary prophylaxis: Multicenter Automatic Defibrillator Implantation Trial (MADIT) criteria, syncope, documented ventricular tachycardia Exclusion Criteria:

  • Severe neurological deficit – Cardiopulmonary resuscitation

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Investigator Details

  • Lead Sponsor
    • Heidelberg University
  • Overall Official(s)
    • Martin Borggrefe, Prof., MD, Study Director, I.Medizinische Klinik, Universitätsklinikum Mannheim
    • M Hennerici, Prof., MD, Study Director, Neurologische Klinik Universitätsklinikum Mannheim
  • Overall Contact(s)
    • Christian Wolpert, PD, MD, +49-621-383-2206, christian.wolpert@med.ma. uni-heidelberg.de

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