Celecoxib Versus Diclofenac In The Treatment Of Osteoarthritis Of The Hip

Overview

To determine if celecoxib 200 mg once daily is as effective as diclofenac 50 mg three times daily in the treatment of pain symptoms associated with osteoarthritis of the hip

Full Title of Study: “Clinical Protocol For A Multicentre, Double-Blind, Randomised, Parallel Group Study To Compare The Efficacy and Tolerability Of Celecoxib Vs. Diclofenac In The Treatment Of Subjects With Osteoarthritis Of The Hip Requiring Joint Replacement Therapy”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double

Interventions

  • Drug: Celecoxib
  • Drug: Diclofenac

Clinical Trial Outcome Measures

Primary Measures

  • Change in patient assessment of arthritis pain on walking VAS (Visual Analog Scale) as measured on a 0-100 mm scale at week 6 compared to baseline

Secondary Measures

  • Change in patient assessment of arthritis pain on walking VAS (Visual Analog Scale) as measured on a 0-100 mm scale at week 12 compared to baseline.
  • Change in patients global assessment of arthritis between treatment groups.

Participating in This Clinical Trial

Inclusion Criteria

  • Diagnosed with osteoarthritis of hip and requiring joint replacement – Eligible for chronic therapy with an NSAID Exclusion Criteria:

  • Hip surgery anticipated within 8 calendar weeks after first visit – Active gastrointestinal disease or recent diagnosis of gastrointestinal ulceration (within 60 days of first visit)

Gender Eligibility: All

Minimum Age: 45 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Pfizer
  • Overall Official(s)
    • Pfizer CT.gov Call Center, Study Director, Pfizer

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