Kinetics of the Finasteride Prostate Induced Apoptosis

Overview

The aim of this study is to evaluate the mechanisms involved in the apoptosis induced by a treatment of finasteride on benign prostate hyperplasia (BPH). Five sets of patients who need a surgical procedure because of low tract urinary symptoms are randomly attributed to one of five sets of treatment: 0, 7, 14, 21 or 28 days of finasteride treatment before the day of the procedure. Prostate histological fragments are conditioned for molecular and histologic studies.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)

Interventions

  • Drug: finasteride

Clinical Trial Outcome Measures

Primary Measures

  • Date of the maximum apoptosis in the prostate tissues treated by finasteride

Secondary Measures

  • Molecular mechanisms involved in BPH finasteride induced apoptosis
  • Decrease in the frequency of the hemorrhagic incidents after the surgical procedure in patients with a treatment using finasteride

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with low tract urinary symptoms needing a surgical procedure – No previous treatment with finasteride – No androgen deficiency; no prostate cancer suspected.

Gender Eligibility: Male

Minimum Age: 40 Years

Maximum Age: 90 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Hospices Civils de Lyon
  • Overall Official(s)
    • Alain RUFFION, MD, Principal Investigator, Hospices Civils de Lyon

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