Treatment of Patients With Major Depressive Disorder With MK0869 (0869-060)(COMPLETED)

Overview

A clinical study to determine the efficacy and safety of an investigational medication (MK0869) in the treatment of depression.

Full Title of Study: “A Double-Blind, Placebo- and Active-Controlled Acute and Extension Study of MK0869 in the Treatment of Patients With Major Depressive Disorder”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: December 2003

Detailed Description

The duration of treatment is 8 weeks.

Interventions

  • Drug: aprepitant
  • Drug: Comparator: placebo (unspecified)

Clinical Trial Outcome Measures

Primary Measures

  • HAMD-17 total score at week 8. Tolerability.
    • Time Frame: at week 8

Secondary Measures

  • CGI-I score at week 8, at least 50% reduction in the HAMD-17 total score, and Sheehan Disability Score at Week 8
    • Time Frame: at week 8

Participating in This Clinical Trial

Patients with Major Depressive Disorder

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Merck Sharp & Dohme LLC
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Medical Monitor, Study Director, Merck Sharp & Dohme LLC

References

Liu KS, Snavely DB, Ball WA, Lines CR, Reines SA, Potter WZ. Is bigger better for depression trials? J Psychiatr Res. 2008 Jul;42(8):622-30. doi: 10.1016/j.jpsychires.2007.07.003. Epub 2007 Sep 7.

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