Assessment of Potential Interactions Between Cocaine and Tolcapone – 1
Overview
The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.
Full Title of Study: “Assessment of Potential Interactions Between Intravenous Cocaine and Tolcapone”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Primary Purpose: Treatment
- Masking: Double
Detailed Description
Double-blind, inpatient study by screening responses to cocaine infusions of 20 and 40 mg i.v. subjects into 1 of 2 treatment groups to assess potential interactions between i.v. cocaine infusion and treatment with tolcapone.
Interventions
- Drug: Tolcapone
Clinical Trial Outcome Measures
Primary Measures
- Safety
Participating in This Clinical Trial
Inclusion Criteria
Volunteers dependent on cocaine and are non-treatment seeking; between 18-45 yrs of age; DSM-4 criteria for cocaine abuse or dependence Exclusion Criteria:
Additional criteria available during screening at the site
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 45 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Overall Official(s)
- Thomas Newton, M.D., Principal Investigator, National Institute on Drug Abuse (NIDA)
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