Assessment of Potential Interactions Between Cocaine and Tolcapone – 1

Overview

The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.

Full Title of Study: “Assessment of Potential Interactions Between Intravenous Cocaine and Tolcapone”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Primary Purpose: Treatment
    • Masking: Double

Detailed Description

Double-blind, inpatient study by screening responses to cocaine infusions of 20 and 40 mg i.v. subjects into 1 of 2 treatment groups to assess potential interactions between i.v. cocaine infusion and treatment with tolcapone.

Interventions

  • Drug: Tolcapone

Clinical Trial Outcome Measures

Primary Measures

  • Safety

Participating in This Clinical Trial

Inclusion Criteria

Volunteers dependent on cocaine and are non-treatment seeking; between 18-45 yrs of age; DSM-4 criteria for cocaine abuse or dependence Exclusion Criteria:

Additional criteria available during screening at the site

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • National Institute on Drug Abuse (NIDA)
  • Overall Official(s)
    • Thomas Newton, M.D., Principal Investigator, National Institute on Drug Abuse (NIDA)

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