Longitudinal and Biological Study of Childhood Disintegrative Disorder

Overview

OBJECTIVES: I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays. II. Collect data on molecular genetics of proband and family members.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Other

Detailed Description

PROTOCOL OUTLINE: Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale – Parent and Teacher version; and Autism Behavior Checklist An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

Participating in This Clinical Trial

  • Psychologically diagnosed (DSM-IV) as Childhood Disintegrative Disorder – No known genetic or medical syndrome (Down syndrome or cerebral palsy) – Must speak English
  • Gender Eligibility: All

    Minimum Age: 2 Years

    Maximum Age: 9 Years

    Are Healthy Volunteers Accepted: No

    Investigator Details

    • Lead Sponsor
      • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
    • Collaborator
      • Yale University
    • Overall Official(s)
      • Fred Volkmar, Study Chair, Yale University

    References

    Volkmar FR, Klin A, Marans WD, et al.: Childhood disintegrative disorder. In: Cohen DJ, Volkmar FR.: Handbook of autism and pervasive developmental disorders. 2nd ed., New York, NY: John Wiley, 1997, pp 47-59.

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