Effect of Estrogen on Mental and Social Functioning in Girls With Turner’s Syndrome
Overview
RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome. Estrogen may be effective treatment for mental and social functioning problems experienced by girls with Turner's syndrome. PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome.
Full Title of Study: “Controlled Study of Estrogen Effects on Cognitive and Social Function in Girls With Turner’s Syndrome”
Study Type
- Study Type: Interventional
- Study Design
- Primary Purpose: Treatment
Detailed Description
PROTOCOL OUTLINE: Participants are evaluated for cognitive and social function at entry and 4 years following entry. Assessments include the Wechsler Intelligence Scale for Children-Revised, a child behavior checklist, the Children's Self-Concept Scale, and visual-spatial, visual-motor, attention, memory, language, and facial recognition tasks. Patients (and parents) undergo X-chromosome analysis; brain magnetic imaging is optional. Controls are matched using school selection and telephone interviews. A study duration of 12 years is estimated.
Interventions
- Drug: Estrogen
Participating in This Clinical Trial
PROTOCOL ENTRY CRITERIA:
- Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype – Age-matched girls without Turner's syndrome entered as controls – Concurrent registration on Thomas Jefferson University growth study required of subjects with Turner's syndrome
Gender Eligibility: Female
Minimum Age: 8 Years
Maximum Age: 12 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
- Collaborator
- Jefferson Medical College of Thomas Jefferson University
- Overall Official(s)
- Judith Levine Ross, Study Chair, Jefferson Medical College of Thomas Jefferson University
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