Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2 – 5
Overview
The purpose of this study is to assess the abuse liability and reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in heroin-dependent volunteers
Full Title of Study: “Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2”
Study Type
- Study Type: Interventional
- Study Design
- Primary Purpose: Treatment
- Masking: Double
- Study Primary Completion Date: November 1999
Detailed Description
not available at this time
Interventions
- Drug: Opioid-Related Disorders
Clinical Trial Outcome Measures
Primary Measures
- Subjective dose estimate
- Observed withdrawal rating
- Opioid antagonist rating
- Pupil diameter
- Analog rating scale for drug effects
- Drug effect characteristics
- Drug/Money Preferences
Participating in This Clinical Trial
Inclusion Criteria
Individuals must be at least 18 yrs of age, currently opioid dependent and must not be seeking treatment. Co-morbid substance abuse or dependence disorders may also be present. Individuals must be healthy despite drug dependency and have a history of IV opioid use. Exclusion Criteria:
Individuals with evidence of an active Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Axis I psychiatric disorder (e.g. psychosis, manic-depressive illness, organic psychiatric disorders), significant medical illness (e.g. liver or cardiovascular disease) or pregnant female subjects are excluded from study participation.
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 65 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- University of Colorado, Denver
- Collaborator
- National Institute on Drug Abuse (NIDA)
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Leslie Amass, Ph.D., Principal Investigator, University of Colorado, Denver
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