Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2 – 5

Overview

The purpose of this study is to assess the abuse liability and reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in heroin-dependent volunteers

Full Title of Study: “Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2”

Study Type

  • Study Type: Interventional
  • Study Design
    • Primary Purpose: Treatment
    • Masking: Double
  • Study Primary Completion Date: November 1999

Detailed Description

not available at this time

Interventions

  • Drug: Opioid-Related Disorders

Clinical Trial Outcome Measures

Primary Measures

  • Subjective dose estimate
  • Observed withdrawal rating
  • Opioid antagonist rating
  • Pupil diameter
  • Analog rating scale for drug effects
  • Drug effect characteristics
  • Drug/Money Preferences

Participating in This Clinical Trial

Inclusion Criteria

Individuals must be at least 18 yrs of age, currently opioid dependent and must not be seeking treatment. Co-morbid substance abuse or dependence disorders may also be present. Individuals must be healthy despite drug dependency and have a history of IV opioid use. Exclusion Criteria:

Individuals with evidence of an active Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Axis I psychiatric disorder (e.g. psychosis, manic-depressive illness, organic psychiatric disorders), significant medical illness (e.g. liver or cardiovascular disease) or pregnant female subjects are excluded from study participation.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Colorado, Denver
  • Collaborator
    • National Institute on Drug Abuse (NIDA)
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Leslie Amass, Ph.D., Principal Investigator, University of Colorado, Denver

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.