IV Cocaine Abuse: A Laboratory Model – 1

Overview

The purpose of this study is to evaluate the effects of desipramine DMI maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving.

Full Title of Study: “IV Cocaine Abuse: A Laboratory Model”

Study Type

  • Study Type: Interventional
  • Study Design
    • Primary Purpose: Treatment
  • Study Primary Completion Date: July 1988

Interventions

  • Drug: Desipramine

Clinical Trial Outcome Measures

Primary Measures

  • Amount cocaine self-administered
  • Direct cocaine effects (cardiovascular, subjective
  • Interaction of cocaine and DMI on cardio measures
  • Interaction of cocaine/DMI on coc’s subjective
  • Effects of DMI on cocaine craving
  • Drug use during outpatient DMI maintenance

Participating in This Clinical Trial

Please contact site for information.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • New York State Psychiatric Institute
  • Collaborator
    • National Institute on Drug Abuse (NIDA)
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Richard Foltin, Ph.D., Principal Investigator, Columbia University

References

Fischman MW, Foltin RW, Nestadt G, Pearlson GD. Effects of desipramine maintenance on cocaine self-administration by humans. J Pharmacol Exp Ther. 1990 May;253(2):760-70.

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